Immediately after updating to iOS 4, some users may notice that Exchange ActiveSync Mail, Contacts, or Calendars do not sync, or sync very slowly. In addition, some Exchange Server administrators may notice their servers running slowly.
To work around this issue, users should install a configuration profile from Apple that increases the amount of time the iOS 4 device will wait for the Exchange Server to respond to its sync requests. For best results, the profile should be installed on as many iOS 4 devices at your company as possible.
Read more and download the configuration profile at - http://support.apple.com/kb/TS3398